Product Name

• Tenoryl Plus 5/5, Reduce Blood Pressure, Prevent Hypertension Complication - 30 Tablets

Scientific Name

• Perindopril 5 Mg + Amlodipine 5 Mg Tablets

Category Of Tenoryl Plus 5/5 Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Perindopril & Amlodipine

• Perindopril belongs to Angiotensin-converting-enzyme inhibitors which are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
• In addition, Perindopril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilator prostaglandins, thereby inhibiting systemic vasoconstriction, regulated by angiotensin II, and promoting systemic vasodilation.
• Amlodipine inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure.

Therapeutic Indications Of Tenoryl Plus 5/5 Tablets

• High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

Method Of Administration Of Tenoryl Plus 5/5 Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• The tablets should be swallowed whole with a glass of water.
• You should try to take your daily dose at about the same time each day.
• You must continue to take the drug until your doctor tells you otherwise.
• Do not break the tablet in half
• You can take the tablet with or without food.
• High blood pressure: The usual dose of the tablets is one tablet once daily, but your doctor may increase the dose to reach the targeted blood pressure
• The use of this medicine is not recommended in children.
• Recommended starting dose must always be 2.5 mg of perindopril arginine and 2.5 mg of amlodipine
• taken as separate tablets in elderly patients.
• This medicinal product is indicated for long-term treatment.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Tenoryl Plus 5/5 Tablets

• Dizziness, headache, vertigo.
• Vision problems.
• Pins and needles sensation.
• Tinnitus (noises in your ears).
• Cough (dry and irritating).
• Swelling of ankles, feet, hands, or joints.
• Edema (swelling and fluid retention).
• Chest pain and difficulty breathing.
• Dry mouth.
• Nosebleeding
• Erectile dysfunction.
• Changes in heart rate or rhythm (fast or irregular).
• Nausea, diarrhea, constipation, indigestion, taste changes, vomiting, abdominal pain
• Low blood pressure, blood vessel inflammation, and flushing.
• Allergic reactions (such as eczema, itching, and skin rash).
• Tiredness and fatigue.
• Drowsiness.
• Muscle cramps.

Pregnancy & Breastfeeding Precautions While Taking Tenoryl Plus 5/5 Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Tenoryl Plus 5/5 Tablets

• Stop the medication right away and talk to your doctor or pharmacist if you develop allergic reactions such as shortness of breath, skin rash, swelling of the face or neck, decreased blood pressure, and dizziness.
• Your doctor may recommend limiting salt intake, following a healthy diet, exercising, and stopping smoking.
• Talk to your doctor if you have hypertrophic cardiomyopathy (heart muscle problem), aortic stenosis (the main blood vessel that leads to the heart becoming narrowed), or renal artery stenosis (artery supplying blood to the kidney becomes narrow).
• Talk to your doctor before starting this medicine if you have liver or kidney problems or if you are undergoing dialysis.
• Talk to your doctor before starting this medicine if you have diabetes.
• Talk to your doctor before starting this medicine if you have collagen vascular diseases (a disorder of the connective tissue) like scleroderma or systemic lupus erythematosus.
• Talk to your doctor before starting this medicine if you have high potassium levels or are following a salt-restricted diet or using salt substitutes that have potassium.
• Talk to your doctor before starting this medicine if you are to have LDL apheresis (cholesterol removal from your blood using a machine)
• Talk to your doctor before starting this medicine if you are due to have surgery and/or anesthesia.
• Talk to your doctor before starting this medicine if you are going to undergo desensitization therapy to decrease the effects of wasp stings or a bee allergy.
• Talk to your doctor before starting this medicine if you are intolerant to some sugars.
• Talk to your doctor before starting this medicine if you have recently suffered from vomiting, diarrhea, or are dehydrated.
• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements.

Storage Conditions Of Tenoryl Plus 5/5 Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Ranges

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Perindopril & Amlodipine

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information About Perindopril & Amlodipine
• Visit Drugs.com at Information About Perindopril & Amlodipine