Product Name

• Arbiten Plus 80/12.5, Reduce Blood Pressure, Prevent Hypertension Complication - 30 Tablets

Scientific Name

• Valsartan 80 Mg + Hydrochlorothiazide 12.5 Mg Tablets

Category Of Arbiten Plus 80/12.5 Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Valsartan & Hydrochlorothiazide

• Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to constrict.
• As a result, valsartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
• Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid.
• Thus it increases urine excretion, which by turn decreases blood volume and finally blood pressure.
• On long-term usage, thiazide diuretic (TZD)-mediated chronic reduction of arterial pressure is thought to occur through decreased total peripheral vascular resistance.

Therapeutic Indications Of Arbiten Plus 80/12.5 Tablets

• Treatment of hypertension in adults, 18 years of age and older.
• Hypertension, high blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

Method Of Administration Of Arbiten Plus 80/12.5 Tablets

• Swallow the tablet whole with a full glass of water
• It is important to take the drug exactly as your doctor or pharmacist has told you.
• The recommended dose is 1 coated tablet per day, your doctor may increase the dose to reach the targeted blood pressure
• The maximum antihypertensive effect is seen within 2 to 4 weeks.
• The maximum daily dose is 320 mg/25 mg.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Arbiten Plus 80/12.5 Tablets

• You should see your doctor immediately if you experience symptoms of angioedema, such as:

1. swollen face, tongue, or pharynx
2. difficulty in swallowing
3. hives and difficulties in breathing

• Severe skin disease that causes rash, red skin, blistering of the lips, eyes, or mouth, skin peeling, fever (toxic epidermal necrolysis)
• Decrease in vision or pain in your eyes due to high pressure (possible signs of fluid accumulation in the vascular layer of the eye (choroidal effusion) or acute angle-closure glaucoma)
• Fever, sore throat, more frequent infections (agranulocytosis)

Pregnancy & Breastfeeding Precautions While Taking Arbiten Plus 80/12.5 Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Arbiten Plus 80/12.5 Tablets

• Do not take this drug:

1. If you are allergic (hypersensitive) to valsartan, hydrochlorothiazide, sulfonamide derivatives (substances chemically related to hydrochlorothiazide), or to any of the other ingredients of this medicine
2. If you are more than 3 months pregnant
3. If you have severe liver disease, destruction of the small bile ducts within the liver (biliary cirrhosis) leads to the buildup of bile in the liver (cholestasis).
4. If you have severe kidney disease.
5. If you are unable to produce urine (anuria).
6. If you are treated with an artificial kidney.
7. If the level of potassium or sodium in your blood is lower than normal, or if the level of calcium in your blood is higher than normal despite treatment.
8. If you have gout.
9. If you have diabetes or impaired kidney function and you are treated with a blood pressure-lowering medicine containing aliskiren.

• Talk to your doctor:

1. If you are taking potassium-sparing medicines, potassium supplements, salt substitutes containing potassium, or other medicines that increase the amount of potassium in your blood such as heparin. Your doctor may need to check the amount of potassium in your blood regularly.
2. If you have low levels of potassium in your blood.
3. If you have diarrhea or severe vomiting.
4. If you are taking high doses of water tablets (diuretics).
5. If you have severe heart disease.
6. If you are suffering from heart failure or have experienced a heart attack. Follow your doctor’s instructions for the starting dose carefully. Your doctor may also check your kidney function.
7. If you suffer from a narrowing of the kidney artery.
8. If you have recently received a new kidney.
9. If you suffer from hyperaldosteronism. This is a disease in which your adrenal glands make too much of the hormone aldosterone.
10. If you have liver or kidney disease

• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Storage Conditions Of Arbiten Plus 80/12.5 Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Range

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Valsartan & Hydrochlorothiazide

• Ask your physician or pharmacist
• SFDA website at Information About Valsartan & Hydrochlorothiazide
• Visit Medscape at Information About Valsartan & Hydrochlorothiazide
• Visit Drugbank at Information About Valsartan & Hydrochlorothiazide
• Visit Drugs.com at Information About Valsartan & Hydrochlorothiazide