Product Name

• Olmetec Plus 40/25, Reduce Blood Pressure, Prevent Hypertension Complication - 28 Tablets

Scientific Name

• Olmesartan 40 Mg + Hydrochlorothiazide 25 Mg Tablets

Category Of Olmetec Plus 40/25 Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Olmesartan & Hydrochlorothiazide

• Olmesartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to constrict.
• As a result, olmesartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
• Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid.
• Thus it increases urine excretion, which by turn decreases blood volume and finally blood pressure.
• On long-term usage, thiazide diuretic (TZD)-mediated chronic reduction of arterial pressure is thought to occur through decreased total peripheral vascular resistance.

Therapeutic Indications Of Olmetec Plus 40/25 Tablets

• Treatment of hypertension.
• You will only be given Olmesartan/hydrochlorothiazide if olmesartan medoxomil alone has not adequately controlled your blood pressure
• High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

Method Of Administration Of Olmetec Plus 40/25 Tablets

• The tablets can be taken with or without food.
• Swallow the tablets with a sufficient amount of water (e.g. one glass).
• If possible, take your daily dose at the same time each day, for example at breakfast time.
• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• The recommended dose is one Olmesartan/hydrochlorothiazide 20 mg/12.5 mg tablet a day.
• However, if your blood pressure is not controlled, your doctor may decide to change your dose to one Olmesartan/hydrochlorothiazide 20 mg/25 mg tablet a day.
• It is important to continue to take Olmesartan/hydrochlorothiazide until your doctor tells you to stop.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Olmetec Plus 40/25 Tablets

• allergic reactions that may affect the whole body
• drop in the blood pressure
• Dizziness, headache, nausea, indigestion, diarrhea, stomach ache, gastroenteritis, tiredness, sore throat, runny or stuffy nose, bronchitis, flu-like symptoms, cough, pain, pain in the chest, back, bones or joints, infection of the urinary tract, swelling of ankles, feet, legs, hands, or arms, blood in the urine.
• Some changes in blood test results have also been seen and include the following: increased fat levels, increased uric acid levels, rise in blood urea, increases in tests of liver and muscle function, increased potassium levels and increased levels of compounds related to kidney function, increase in blood creatinine, urea, calcium and sugar levels, decrease in blood chloride, potassium, magnesium and sodium levels, increase of serum amylase and reduction of the numbers of a type of blood cell, known as platelets.
• Lack of energy, muscle cramps, impaired kidney function, kidney failure.
• Decreased or loss of appetite.
• Swollen and sore salivary glands, bone marrow damage, restlessness, feeling depressed, problems sleeping, apathy, tingling and numbness, convulsions, blurred vision, dry eyes, irregular heartbeat, inflammation of the blood vessels, blood clots, inflammation of the lung, fluid accumulation in the lungs, inflammation of the pancreas, jaundice, infection in the gallbladder.
• Electrolyte disturbance leading to an abnormally depleted level of chloride in the blood.

Pregnancy & Breastfeeding Precautions While Taking Olmetec Plus 40/25 Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Olmetec Plus 40/25 Tablets

• Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.
• In particular, tell your doctor or pharmacist about any of the following:

1. Other blood pressure-lowering medicines
2. Medicines that may alter the levels of potassium in your blood
3. Lithium
4. Non-steroidal anti-inflammatory medicines
5. Sleeping tablets, sedatives, and antidepressant medicines
6. Certain medicines which used to relax muscles.
7. Certain drugs used to treat cancers
8. Medicines for lowering blood fat levels.
9. Colesevelam hydrochloride, a drug that lowers the level of cholesterol in your blood
10. Anticholinergic agents, such as atropine and biperiden.
11. Drugs which used to treat certain psychiatric disorders.
12. Certain medicines which used to treat heart problems.
13. Medicines that may change the heart rhythm.
14. Oral anti-diabetic medicines, such as metformin, or insulin, which used to lower blood sugar.
15. Medicines such as noradrenaline, which used to increase blood pressure and slow heart rate.

Storage Conditions Of Olmetec Plus 40/25 Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Ranges

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Olmesartan & Hydrochlorothiazide

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information About Olmesartan & Hydrochlorothiazide
• Visit Drugs.com at Information About Olmesartan & Hydrochlorothiazide