Product Name

• Esidrex 25 Mg, Reduce Blood Pressure, Prevent Hypertension Complication - 20 Tablets

Scientific Name

• Hydrochlorothiazide 25 Mg Tablets

Category Of Esidrex 25 Mg Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Hydrochlorothiazide

• Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid.
• Thus it increases urine excretion, which by turn decreases blood volume and finally blood pressure.
• On long-term usage, thiazide diuretic (TZD)-mediated chronic reduction of arterial pressure is thought to occur through decreased total peripheral vascular resistance.

Therapeutic Indications Of Esidrex 25 Mg Tablets

• To treat patients with high blood pressure (hypertension): High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
• Also, used to treat water buildup in your body (edema) due to problems with your heart, kidneys, liver, or blood vessels.

Method Of Administration Of Esidrex 25 Mg Tablets

• Take as indicated by your doctor.
• Take with a glass of water.
• If you are taking this medicine once daily, take it in the morning.
• For water retention: the usual starting dose is 25 - 100 mg daily in 1 to 2 divided doses. Your doctor will adjust the dose for you based on your response (maximum 200 mg/day).
• For high blood pressure: the usual dosing is 12.5 - 25 mg once daily (maximum 50 mg/day).
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Esidrex 25 Mg Tablets

• Stop using this product and seek immediate medical help if you develop a rash; hives; itching; red, swollen, blistered, or peeling skin; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Serious side effects:

1. Kidney problems
2. Eye problems
3. Serious electrolyte problems

Pregnancy & Breastfeeding Precautions While Taking Esidrex 25 Mg Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron, Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Esidrex 25 Mg Tablets

• Talk to your doctor about all your medical conditions before taking this medicine including:

1. If you are allergic to sulfonamide antibiotics or sulfonylureas.
2. If you have kidney problems.
3. If you have liver problems.
4. If you have heart problems.
5. If you have diabetes.
6. If you have low blood pressure.
7. If you are dehydrated.
8. If you have abnormal electrolyte levels in your blood.
9. If you have glaucoma.
10. If you have gout.
11. If you have an autoimmune disease called systemic lupus erythematosus (SLE).

• Hydrochlorothiazide interacts with the following medicines:

1. Lithium
2. Digoxin
3. Other medicines used to lower blood pressure
4. Medicines that affect potassium levels in your blood
5. Medicines used for diabetes
6. Non-steroidal anti-inflammatory drugs
7. Steroids
8. Cholestyramine and Colestipol (for cholesterol)

Storage Conditions Of Esidrex 25 Mg Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Range

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Hydrochlorothiazide

• Ask your physician or pharmacist
• Visit Medscape at Information About Hydrochlorothiazide
• Visit Drugbank at Information About Hydrochlorothiazide
• Visit Drugs.com at Information About Hydrochlorothiazide
• SFDA website at Information About Hydrochlorothiazide