Product Name

• Twynsta 80/5, Reduce Blood Pressure, Prevent Hypertension Complication - 28 Tablets

Scientific Name

• Telmisartan 80 Mg + Amlodipine 5 Mg Tablets

Category Of Twynsta 80/5 Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Telmisartan & Amlodipine

• Telmisartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to constrict.
• As a result, Telmisartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
• Amlodipine inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure.

Therapeutic Indications Of Twynsta 80/5 Tablets

• It is indicated in patients whose blood pressure is not adequately controlled on Telmisartan or amlodipine monotherapy
• High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
• Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

Method Of Administration Of Twynsta 80/5 Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• The tablets should be swallowed whole with a glass of water.
• You should try to take your daily dose at about the same time each day.
• You must continue to take the drug until your doctor tells you otherwise.
• Do not break the tablet in half
• You can take the tablet with or without food.
• High blood pressure: The usual dose of the tablets is one tablet once daily, but your doctor may increase the dose to reach the targeted blood pressure
• The maximum recommended dose is one tablet 80 mg telmisartan/10 mg amlodipine per day.
• This medicinal product is indicated for long term treatment.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Twynsta 80/5 Tablets

• Dizziness, ankle swelling (edema).
• Sleepiness
• Migraine, headache
• Tingling or numbness of the hands or feet
• A feeling of spinning (vertigo)
• Slow heart rate, palpitations (awareness of your heartbeat), low blood pressure (hypotension)
• Dizziness on standing up (orthostatic hypotension)
• Flushing
• Cough
• Stomach ache (abdominal pain), diarrhea
• Feeling sick (nausea), itching, joint pain, muscle cramps, muscle pain
• Inability to obtain an erection
• Weakness
• Chest pain
• Tiredness
• Increased levels of hepatic enzymes.

Pregnancy & Breastfeeding Precautions While Taking Twynsta 80/5 Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Twynsta 80/5 Tablets

• Talk to your doctor before taking Twynsta if you are suffering or have ever suffered from any of the following conditions or illnesses:

1. Kidney disease or kidney transplant.
2. Narrowing of the blood vessels to one or both kidneys (renal artery stenosis).
3. Liver disease.
4. Heart trouble.
5. Raised aldosterone levels (which lead to water and salt retention in the body along with imbalance
6. of various blood minerals).
7. Low blood pressure (hypotension), likely to occur if you are dehydrated (excessive loss of body water) or have salt deficiency due to diuretic therapy (‘water tablets’), low-salt diet, diarrhea, or vomiting.
8. Elevated potassium levels in your blood.
9. Diabetes.
10. Narrowing of the aorta (aortic stenosis).
11. Heart-associated chest pain also at rest or with minimal effort (unstable angina pectoris).
12. A heart attack within the last four weeks.

• Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines that include vitamin & non prescribed drug

Storage Conditions Of Twynsta 80/5 Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Ranges

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Telmisartan & Amlodipine

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information About Telmisartan & Amlodipine
• Visit Drugs.com at Information About Telmisartan & Amlodipine