Product Name

• Simvagen 20 Mg, Reduce Blood Cholesterol Level & Prevent Hyperlipidemia Complications - 30 Tablets

Scientific Name

• Simvastatin 20 Mg Tablets

Category Of Simvagen 20 Mg Tablets

• Anti-Hypercholesterolemia Drugs

Mechanism Of Action Of Simvastatin

• Simvastatin is a cholesterol-lowering medication that belongs to the statin class of drugs. Statins lower cholesterol levels in the blood by blocking 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase, an enzyme that's needed for the liver to produce cholesterol.
• Decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low-density lipoprotein (LDL) receptors, which increases hepatic uptake of LDL & decreases LDL level in the blood.

Therapeutic Indications Of Simvagen 20 Mg Tablets

• It is used to lower lipids known as cholesterol and triglycerides in the blood when a low-fat diet and lifestyle changes on their own have failed.
• Cholesterol is a naturally occurring substance in the body necessary for normal growth. However, if there is too much cholesterol in your blood, it can build up on blood vessel walls, increasing the risk of blood clots and cardiovascular events. This is one of the most common causes of heart disease.
• You should maintain a standard cholesterol-lowering diet during treatment.

Method Of Administration Of Simvagen 20 Mg Tablets

• You should stay on a cholesterol-lowering diet while taking Simvastatin.
• Dosage: The recommended dose is simvastatin 5 mg, 10 mg, 20 mg, 40 mg, or 80 mg by mouth once daily
• Your doctor will determine the appropriate tablet strength for you, depending on your condition, your current treatment and your personal risk status.
• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• Simvastatin tablets can be taken at any time of day, but the most common instruction is to take your statin at night. This is because cholesterol production is thought to be highest at night
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Simvagen 20 Mg Tablets

• Although the following side effects are not common in everyone, some patients may complain from:

1. Muscle weakness, tenderness, pain, rupture. On rare occasions, these muscle problems can be serious, including muscle breakdown resulting in kidney damage; and very rare deaths have occurred. Ron-Co Q10 Capsules may help to reduce muscle pain
2. Swelling of the face, tongue, and throat may cause difficulty in breathing (angioedema)
3. Rash with weakness of limbs and neck muscles
4. Pain or inflammation of the joints (polymyalgia rheumatica)
5. Inflammation of the blood vessels (vasculitis)
6. Unusual bruising, skin eruptions and swelling (dermatomyositis), hives, skin sensitivity to the sun, fever, flushing,
7. Shortness of breath (dyspnea) and feeling unwell
8. Lupus-like disease picture (including rash, joint disorders, and effects on blood cells) inflammation of the liver with the following symptoms: yellowing of the skin and eyes, itching, dark-colored urine or pale-colored stool, feeling tired or weak, loss of appetite; liver failure (very rare)
9. Inflammation of the pancreas often causes severe abdominal pain.

Pregnancy & Breastfeeding Precautions While Taking Simvagen 20 Mg Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding

Non-Pharmacological Treatments & Advice To Reduce Cholesterol Level In The Blood

• Reduce saturated fats. Saturated fats, found primarily in red meat and full-fat dairy products, raise your total cholesterol.
• Eliminate trans fats. Trans fats, sometimes listed on food labels as "partially hydrogenated vegetable oil," are often used in margarine and store-bought cookies, crackers, and cakes. Trans fats raise overall cholesterol levels.
• Eat foods rich in omega-3 fatty acids or use an omega-3 supplement like Omegat Omega 3 Capsules or Paradox Omega 3 Capsules
• Increase soluble fiber. Soluble fiber can reduce the absorption of cholesterol into your bloodstream. Soluble fiber is found in such foods as oatmeal, kidney beans, Brussels sprouts, apples, and pears.
• Exercise on most days of the week and increase your physical activity, work up to at least 30 minutes of exercise five times a week
• Quitting smoking improves your HDL cholesterol level.
• Losing weight will help you to reduce your triglyceride levels. A 5–10 percent weight loss can decrease triglyceride levels by 20 percent. Rondiet Capsules & Ronfit Capsules will help you to decrease your body weight
• Sometimes healthy lifestyle changes aren't enough to lower cholesterol levels. If your doctor recommends medication to help lower your cholesterol, take it as prescribed while continuing your lifestyle changes. Lifestyle changes can help you keep your medication dose low.

Warnings & Special Precautions while Taking Simvagen 20 Mg Tablets

• Do not use Simvastatin

1. if you are allergic (hypersensitive) to simvastatin or any of the other ingredients of this medicine
2. if you currently have liver problems
3. if you are pregnant or breast-feeding

• Tell your doctor:

1. about all your medical conditions including allergies
2. if you have ever had liver disease. Simvastatin may not be right for you
3. if you are due to have an operation. You may need to stop taking Simvastatin tablets for a short time
4. if you are Asian, because a different dose may be applicable to you.

• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements.

Storage Conditions Of Simvagen 20 Mg Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Ranges

• According to MedlinePlus

• Anyone age 19 or younger:

1. Total Cholesterol: Less than 170 mg/dL
2. Non-HDL: Less than 120 mg/dL
3. LDL: Less than 100 mg/dL
4. HDL: More than 45 mg/dL

• Men age 20 or older:

1. Total Cholesterol: 125 to 200 mg/dL
2. Non-HDL: Less than 130 mg/dL
3. LDL: Less than 100 mg/dL
4. HDL: 40 mg/dL or higher

• Women age 20 or older:

1. Total Cholesterol: 125 to 200 mg/dL
2. Non-HDL: Less than 130 mg/dL
3. LDL: Less than 100 mg/dL
4. HDL: 50 mg/dL or higher

• The exact values may be changed based on the used guideline

For More Information About Simvastatin

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information About Simvastatin
• Visit Drugs.com at Information About Simvastatin
• Visit Drugbank.com at Information About Simvastatin