How to use: Sterile with cleaner and water the derma roller. Recommended to use it with cleaned face and without make up. Use the roller four to five times back and forth on every spot and direction of the face and nose. Recommended to put Serum Vitamin C after the derma roller to get great results. For first time- Recommended to use Derma Roller 0.25 MM. After months, you can use larger size. Derma Roller 0.25 MM could be used between two to three times on weekly basis. Derma Roller 0.5 MM could be used once per week. No side Effects mentioned. Suitable for All Ages. Suitable for All Skin Types. Suitable for Pregnant and Lactating Women.