Product Name

• Janumet, Sitagliptin/Metformin, Extended-Release, Tablet, 50/1000 Mg - 56 Tablets

Scientific Name

• Sitagliptin 50 Mg + Metformin 1000 Mg Extended-Release Tablets

Category Of Janumet XR 50/1000 Tablets

• Oral Anti-Diabetic Drugs

Mechanism Of Action Of Sitagliptin & Metformin

• Sitagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1). Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed.
• Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis)
• Metformin decreases the intestinal absorption of glucose
• Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization

Therapeutic Indications Of Janumet XR 50/1000 Tablets

• This medicine is used to treat a type of diabetes called “type 2 diabetes”
• Sitagliptin and metformin work together to control your blood sugar.
• They increase the levels of insulin after a meal. They also lower the amount of sugar made by your body.
• Along with diet and exercise, this helps lower your blood sugar.
• This medicine can be used alone or together with other antidiabetic medicines, including insulin.

Method Of Administration Of Janumet XR 50/1000 Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• If you have reduced kidney function, your doctor may prescribe a lower dose.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Janumet XR 50/1000 Tablets

• Although the following side effects are not common in everyone, some patients may complain from:

1. Low blood sugar
2. Nausea, flatulence, vomiting.
3. Diarrhea, constipation
4. Drowsiness.

Pregnancy & Breastfeeding Precautions While Taking Janumet XR 50/1000 Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding

Non-Pharmacological Treatments & Advice For Diabetic Patients

• All carbohydrates affect blood glucose levels so it’s important to know which foods contain carbohydrates. Choose the healthier foods that contain carbs and be aware of your portion sizes.
• Eat less salt. Eating lots of salt can increase your risk of high blood pressure, which in turn increases the risk of heart diseases and stroke. And when you have diabetes, you’re already more at risk of all of these conditions.
• Eat more fruit and vegetables. This can help you get the vitamins, minerals, and fiber your body needs every day to help keep you healthy.
• You can always try low or zero-calorie sweeteners (also known as artificial sweeteners) to help you cut down sugar for example Steviana Sweetener or Tropicana Slim Sweetener
• Don’t forget to keep moving. Being more physically active goes hand in hand with eating healthier.
• Remember to measure your blood glucose level continuously by using home monitor like Accu-Check, Instant, Blood Glucose Monitor
• Thiozac Capsules & Neurobion Tablets will help you to reduce neuropathy induced by diabetes
• If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, fast heart beating, vision disorders, or difficulty in concentration, it usually helps to eat or drink something containing sugar.

Warnings & Special Precautions while Taking Janumet XR 50/1000 Tablets

• Talk to your doctor or pharmacist before taking:

1. If you have or have had a disease of the pancreas (such as pancreatitis)
2. If you have or have had gallstones, alcohol dependence, or very high levels of triglycerides (a form of fat) in your blood.
3. If you have type 1 diabetes. This is sometimes called insulin-dependent diabetes
4. If you have or have had an allergic reaction to sitagliptin, metformin
5. If you are taking sulfonylurea or insulin, diabetes medicines, together with it

• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements.

Storage Conditions Of Janumet XR 50/1000 Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Ranges

• Random blood sugar test: A blood sample will be taken at a random time. Regardless of when you last ate, a blood sugar level of 200 milligrams per deciliter (mg/dL) or higher suggests diabetes. A blood sugar level of less than 140 mg/dL is normal. A reading between 140 and 199 mg/dL indicates prediabetes
• Fasting blood sugar test. A blood sample will be taken after an overnight fast. A fasting blood sugar level of less than 100 mg/dl is normal. A fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes. If it's 126 mg/dL or higher on two separate tests, you may have diabetes.
• Oral glucose tolerance test: For this test, you fast overnight, and the fasting blood sugar level is measured. Then you drink a sugary liquid, and blood sugar levels are tested periodically for the next two hours.

For More Information About Sitagliptin & Metformin

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information About Sitagliptin & Metformin
• Visit Drugs.com at Information About Sitagliptin & Metformin