Product Name

• Acetab 25 Mg, Reduce Blood Pressure, Prevent Hypertension Complication - 30 Tablets

Scientific Name

• Captopril 25 Mg Tablets

Category Of Acetab 25 Mg Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Captopril

• Captopril belongs to Angiotensin-converting-enzyme inhibitors which are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
• In addition, Captopril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilator prostaglandins, thereby inhibiting systemic vasoconstriction, regulated by angiotensin II, and promoting systemic vasodilation.

Therapeutic Indications Of Acetab 25 Mg Tablets

• Treat high blood pressure (hypertension): High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
• Treat chronic heart failure (when the heart is not strong enough to work correctly)
• Treat a heart attack:

1. In the short-term (4 weeks), to treat clinically stable patients. In this case, treatment will be started within the first 24 hours of the attack
2. In the long-term, to prevent symptomatic heart failure

• Treat kidney disease in patients with diabetes with High blood pressure

Method Of Administration Of Acetab 25 Mg Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• You can take the tablets before, during, or after meals
• High blood pressure (hypertension):

1. The recommended starting dose is 25-50 mg daily divided into two doses. The dose may be gradually increased until your target blood pressure is reached.
2. The maximum dose is 100-150 mg per day.

• Heart failure:

1. Your doctor will start your treatment under close medical supervision. The usual starting dose is 6.25 mg or 12.5 mg either two or three times a day. The dose may be gradually increased, depending on your response to the treatment.
2. The maintenance dose is 75 to 150 mg per day, divided into two or three doses. The maximum dose is 150 mg per day

• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Acetab 25 Mg Tablets

• Common (may affect up to 1 in 10 people):

1. Sleep disorders
2. Alterations of taste
3. Dizziness
4. Dry, irritant cough without phlegm and/or shortness of breath (dyspnea)
5. Feeling sick and/or vomiting
6. Irritation of the stomach, abdominal pain, diarrhea, constipation, dry mouth
7. Itchy skin with or without a rash, rash, hair loss

• Uncommon (may affect up to 1 in 100 people):

1. Fast heartbeat (tachycardia) and/or fast, irregular heartbeat (tachyarrhythmia)
2. Chest pain and/or chest pain due to a lack of blood and hence oxygen supply of the heart muscle (angina pectoris)
3. Feeling the heart beating in the chest (palpitations)
4. Low blood pressure (hypotension)
5. Pain in fingers or toes while they turn first whitish, then bluish, and finally reddish (Raynaud’s syndrome)
6. Flushes and/or paleness of the skin
7. Swelling of the skin particularly of the face and around the mouth (angioedema).
8. Tiredness and/or feeling unwell
9. Rare (may affect up to 1 in 1,000 people):
10. Loss of appetite
11. Drowsiness and/or headache
12. Tingling, pricking, or numbness of the skin (paresthesia)
13. Soreness of the mouth (stomatitis) and/or sores (ulcers) in the mouth
14. Changes in kidney function include kidney failure, passing more water than normal (polyuria), passing less water than normal (oliguria), passing water more often than normal
15. Allergic reaction in the gut causing severe abdominal pain (intestinal angio-edema)

• Very rare (may affect up to 1 in 10,000 people): Changes in blood count

Pregnancy & Breastfeeding Precautions While Taking Acetab 25 Mg Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Acetab 25 Mg Tablets

• Please consult your doctor if you are using:

1. Potassium-sparing diuretics such as spironolactone, triamterene, or amiloride. These are water tablets that decrease the amount of potassium in the urine.
2. Potassium supplements (including potassium-containing salt substitutes), potassium-sparing diuretics.
3. Other medicines that can increase the amount of potassium in your blood (e.g. trimethoprim and co-trimoxazole also known as trimethoprim/sulfamethoxazole for infections caused by bacteria.
4. ciclosporin, an immunosuppressant medicine used to prevent organ transplant rejection
5. heparin, a medicine used to thin blood to prevent clots).
6. Thiazide or loop diuretics (water tablets).
7. Other blood pressure-lowering drugs (e.g. beta-blockers, methyldopa, calcium antagonists).
8. Medicines for mental illnesses and depression (e.g. lithium, tricyclic antidepressants, antipsychotics).
9. Anesthetics (when you undergo surgery e.g. at the dentist’s or in hospital).
10. Allopurinol (to treat gout).
11. Procainamide (a heart medicine).
12. Cytostatics (anticancer medication).
13. Systemic corticosteroids.
14. Immunosuppressants (medicines that reduce the activity of the immune system).
15. Certain medicines for pain or inflammation (non-steroidal anti-inflammatory drugs, NSAIDs)
16. Sympathomimetics.
17. Blood sugar-lowering medicines (antidiabetics).
18. Antacids.

Storage Conditions Of Acetab 25 Mg Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Range

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Captopril

• Ask your physician or pharmacist
• SFDA website at Information About Captopril
• Visit Medscape at Information About Captopril
• Visit Drugbank at Information About Captopril
• Visit Drugs.com at Information About Captopril