DESCRIPTION:
The combination of tylosin and doxycycline has an additional mode of
action. Doxycycline belongs to the group of tetracyclines and has a
bacteriostatic activity against many Gram-positive and Gram-negative
bacteria like Staphylococcus spp., Diplococcus pneumonia, Streptococcus
spp., Haemophilus influenza, E. coli, Pneumococci, Bacillus anthracis,
Clostridium tetani and Cl. perfringens, Listeria monocytogenes,
Actinomyces spp., Enterobacter spp., Klebsiella spp., Salmonella spp.,
Shigella spp. and Yersinia spp. Doxycycline is also active against
Mycoplasma spp. (M. pneumonia), Rickettsiae and Chlamydia spp. After
oral administration, doxycycline will be well resorted and effective
blood levels will be obtained quickly, persisting for a considerable
time.
This is caused by the relative large half-life time of doxycycline.
Doxycycline is especially recommended for the treatment of bacterial
respiratory infections. Tylosin is a macrolide antibiotic with a
bacteriostatical activity against mainly Gram-positive bacteria and
cocci (Gram-negative Meningococci and Gonococci). It is effective
against the following bacteria: Staphylococcus spp., Streptococcus spp.,
Corynebacterium spp., Neisseria spp., Flavobacterium spp.,
Campylobacter spp., Bacillus anthracis, Moraxella bovis Clostridium
spp., Haemophilus spp., Bordetella bronchiseptica, Spirochetes
(especially Treponema hyodysenteriae) and obligate anaerobe organisms
(like M. hyosynovial, M. hyorhinis, M. hyopneumoniae and M. caprae).
Insensitive are the mycobacteria, Nocardia spp. and fungus. After oral
administration, therapeutic blood levels will be reached within 2 – 4
hours.
INDICATIONS:
Tylo-Dox Extra wsp is effective against infections caused by
micro-organisms sensitive to tylosin and doxycycline in calves, poultry
and pigs. Especially indicated for the treatment of gastrointestinal and
respiratory infections.
DOSAGE AND ADMINISTRATION:
For oral administration via feed or drinking water.
- Calves : 1.25 g per calf of 50 kg bodyweight daily, during 3 – 5 days.
- Pigs : 100 g per 200 – 400 litres of drinking water daily, during 3 – 5 days.
- Poultry : 100 g per 200 – 400 litres of drinking water daily, during 3 – 5 days.
- Mixed with feed : 1 kg per 1,000 kg of complete feed, during 2 – 5 days.
The above mentioned dosage for pigs and poultry can be doubled without any danger for the animals.
Mixed with feed, the product should be used immediately. Medicated drinking water should be used within 24 hours.