Xarelto is a medicine that inhibits platelet aggregation. The active ingredient of Xarelto - rivaroxaban - inhibits the activity of a specific factor (factor Xa) in the coagulation system, thus preventing the formation of blood clots in the veins (= thrombi) or can be used to treat existing blood clots in the leg veins. Bigger clots can clog the veins and the blood circulation to prevent (= thrombosis). You can also dislodge and travel via the circulation to the lungs, where they Shut large and small blood vessels (pulmonary embolism), thereby affecting the function of the lungs significantly. Blood clots can also occur in the heart in certain circumstances. If you release them, they can Shut blood vessels in the brain (stroke) or other organs and parts of the body (systemic embolism). Various factors may favor the emergence of a blood clot. Xarelto is used, the formation of blood clots after major surgery of the lower limbs (eg hip, knee surgery) to prevent. to treat blood clots in the lungs (pulmonary embolism) and / or in the deep veins of the legs (deep vein thrombosis) and to prevent, preventing the formation of blood clots in the leg veins, and pulmonary embolism again. to prevent existing in non-valvular atrial fibrillation (atrial fibrillation, which is not caused by a defective heart valve) the occurrence of blood clots in the brain (stroke) and other blood vessels in your body. Xarelto tablets should be used only when prescribed by a physician or health care professional. What should I be aware of? It is important that you are taking Xarelto in the prescribed by your doctor / health care professional dosage and duration. Keep strictly to the instructions of your doctor / health care professional is. When should Xarelto not be used? Xarelto should not be used if you allergic reaction to the drug rivaroxaban or any other part of this medicine (see section "What is in Xarelto?") suffering from an inflammatory heart disease severe bleeding (eg brain or stomach bleeding) suffer from an active peptic ulcer have severely impaired liver function or have severe liver disease that is associated with an increased risk of bleeding have severely impaired renal function and therefore are having dialysis are pregnant or breast-feeding (see relevant section). Take special care with Xarelto? Xarelto should be used with caution if you have a moderate or severe renal impairment have a moderate hepatic impairment have an extension of the airways (bronchi) have an increased risk of bleeding such as: congenital or acquired bleeding disorders a very high blood pressure (which is not controlled by medical treatment) Problems with the blood vessels in the posterior part of the eye (retinopathy) recently encountered bleeding in the brain recently performed surgery on the brain, spinal or ophthalmic surgery recently suffered from a stomach ulcer a past pulmonary hemorrhage If any of these apply to you, tell your doctor or health care professional before taking Xarelto. If you have an operation is necessary, it is very important that you take Xarelto before and after the operation exactly at the times that have been provided to you by your doctor / health care professional. Xarelto contains lactose (milk sugar). If you have an intolerance to some sugars, you should contact your doctor before taking Xarelto. If you are taking medicines for fungal infections (eg, ketoconazole), antiviral medicines for HIV / AIDS (eg, ritonavir), antibiotics (eg, clarithromycin) or other medicines that reduce blood clotting (eg, clopidogrel) or anti-inflammatory drugs and pain relievers (eg, naproxen or aspirin) tell your doctor or health care professional before taking Xarelto. The effect of Xarelto could be enhanced by these drugs. The concomitant use of other drugs such as some epilepsy (eg phenobarbital, phenytoin, carbamazepine) or rifampicin (an antibiotic) can influence the effect of rivaroxaban, the drug Xarelto.