"This book is a tour de force in the title area....This book adopts a novel format that focuses on the rational chemical underpinnings to both drug discovery and drug development. It seeks to illuminate the workings of drugs at the molecular level. Thus, this book contrasts with the traditional presentation which is organized around various classes of drugs....This book would be appropriate for advanced undergraduate students and graduate students and would probably be well suited as a text for course applications, especially at the graduate level. It is strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."--Bruce E. Maryanoff, R.W. Jouhnson Pharnaceutical Research Institute, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vo. 115, No.12, 1993 "For the first time the principles of medicinal chemistry/pharmacology are collected in a unified, well-organized and clearly presen...