* For weight loss and weight maintenace.* Indications:  – Obesity management, including weight loss, and weight maintenance, in conjunction with dietary modification.  – Reducing weight for obese diabetic subjects.* Precautions:  – Patients should be advised to adhere to dietary guidelines. If orlistat is taken with a meal very high in fat,  the possibility of gastrointestinal side effects increases.  – Patients should be counseled to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition,  because orlistat is shown to reduce the absorption of some fat-soluble vitamins and beta-carotene.  The supplement should be taken at least 2 hours before or after an orlistat dose or at bedtime.  – Caution should be exercised when prescribing orlistat to patients with history of hyperoxaluria or calcium oxalate nephrolithiasis.  – Weight-loss induction by orlistat may be accompanied by improved metabolic control in diabetics, which might require  a reduction in the dose of oral hypoglycemic medication (e.g., sulfonylureas, metformin) or insulin.  – Orlistat adds to the lipid-lowering effect of pravastatin.* Dosage and administration:  – 120 mg capsule (one capsule) three times a day with each main meal containing fat (during or up to 1 hour after the meal).  – If a meal is occasionally missed or contains no fat, the dose of Slim-Safe® can be omitted.  – Doses above 120 mg three times a day have not been shown to provide additional benefit.* Pregnancy & Lactation:  – Pregnancy: Category B.  – It is not known if orlistat is secreted in human milk. Therefore, it should not be taken by lactating women.* Contraindications:  – Orlistat is contraindicated in patients with chronic malabsorption syndrome or cholestasis, and in patients with known  hypersensitivity to the product.* Store between 15-30 degrees C.* Product of: Amoun Pharmaceutical Co. SAE - Egypt.