We are trying to prepare a complete and comprehensive but simple series that was entitled (CARDIO-NOTES) to provide my colleagues; the resident physicians and all interested and involved physicians with a practical full sided reference that will cover all topics in cardiovascular medicine.This second part (CVS drugs) is reviewing the clinical aspects of drugs used in cardiovascular medicine. In which, I have formulated a skeleton to review all CVS drugs in a simple and practical manner starting from mechanism of action till practical tips for each class of drugs including indications, contraindications, members and doses, adverse reactions, and drug interactions supplemented with practical recommendations for dealing with these side effects and interactions.