* Indications: Aprovel is used in the treatment of high blood pressure (hypertension) and for the protection of the kidney in hypertensive type 2 diabetic patients with laboratory evidence of impaired renal function.* Contraindications: – Second or third trimester of pregnancy, Breast-feeding – Allergy to any of the ingredients.* Precautions: # There are certain conditions that you may have, or have had, which require special care before or while taking Aprovel . Therefore, before taking this medicine, you should have told your doctor if you suffer from: – excessive vomiting or diarrhoea, - kidney problems, - heart problems, # If you are to undergo any surgery or receive anaesthetics, you should make sure the doctor knows that you are taking Aprovel tablets.*Psology and method of administration: – The tablets should be taken regularly as directed by your doctor. – Treatment usually starts with 150 mg once a day. The dose may later be increased to 300 mg once daily depending on blood pressure response. – The maximal blood pressure lowering effect should be reached 4-6 weeks after beginning treatment. – If you have the impression that the effect of Aprovel is too strong or too weak, talk to your doctor or pharmacist. – In patients with high blood pressure and type 2 diabetes, 300 mg once daily is the preferred maintenance dose for the treatment of associated kidney disease. – The doctor may advise a lower dose, especially when starting treatment in certain patients such as those on haemodialysis, or those over the age of 75 years. – Aprovel can be taken with or without food. The tablets should be swallowed with a drink of water. You should try ot take your daily dose at about the same time each day. – It is important that you continue to take Aprovel until your doctor tells you otherwise. – Aprovel should not be given to children (<18 years).* Prescription only medicine - List I. Medicinal product subject to medical prescription. Oral use.* Before use, please read the package leaflet. Keep to the prescribed doses.* Do not store above 30 degrees C. Store in the original package.* Manufacturer: Sanofi Winthrop Industrie - France. Importers: Ramco Corporation Marketing Authorization Holder: Sanofi Pharma Bristol Myers Squibb SNC - France (sanofi-synthelabo).