Now Introducing the Latest 100% Pharmaceutical Grade SUPERFLEX-6! Newton Everett® has proven their commitment in helping you receive the best joint care available for the past 8 years! And now we are excited to provide you with an advanced formula of our Superflex-3 formula: SUPERFLEX-6! This new formula contains the original ingredients plus Hyaluronic Acid for lubrication, Boswellia for inflammation and Vitamin D for extra bone and joint health. 2 Tablets per day gives you: • GLUCOSAMINE: 1500mg • CHONDROITIN: 1200mg • MSM: 250mg • HYALURONIC ACID: 40mg • BOSWELLIA: 100mg • VITAMIN D3: 400IU TRIPLE STRENGTH SUPERFLEX-6 ONLY TWO TABLETS PER DAY! • Six joint support products in one high potency formula • Promotes healthy joint tissue and cartilage • Increases joint comfort, freedom from stiffness and ease of movement • Take only two tablets per day as opposed to three   Research strength levels of the six joint support nutrients in SUPERFLEX-6: Glucosamine, Chondroitin, MSM, Hyaluronic Acid, Boswellia and Vitamin D3 have been combined for total joint health, including cartilage and tissue support and enhanced mobility. Try it and discover why millions of people rely on SUPERFLEX-6 nutrients for joint support. WHAT IS GLUCOSAMINE AND HOW DOES IT WORK? Healthy cartilage needs three things: water for lubrication and nourishment, proteoglycans to attract and hold the water and collagen to keep the proteoglycans in place. Proteoglycans are like a rope that threads itself through collagen, which both lubricates and nourishes. If cartilage is damaged, the thread of rope becomes weak and “leaks” out and thus the collagen loses its nourishment as the proteoglycans lose their grip and float away. Thus the cartilage cannot withstand shocks, cracks and may wear out completely. Glucosamine is a major building block of the water—loving proteoglycans. Besides being a building block for the synthesis of proteoglycans, its mere presence acts as a stimulus to the cells that produce proteoglycans—in fact glucosamine is a key factor in determining how many proteoglycans are produced by the cells. Glucosamine has been shown to speed up production of both proteoglycans and collagen and it normalises cartilage metabolism which helps keep cartilage from breaking down. Thus because of the affect of glucosamine on cartilage metabolism it can in fact help the body repair damaged or eroded cartilage. In other words, glucosamine strengthens your body’s natural repair mechanisms. Besides stimulating cartilage production, glucosamine also reduces joint pain and inflammation. CHONDROITIN SULPHATE: Where glucosamine helps form the proteoglycans that sit within the space in the cartilage, chondroitin sulphate acts like “liquid magnets”. Chondroitin is a long chain of repeating nigans that attracts fluid into the proteoglycan molecules. This is important for two reasons. 1.) The fluid acts as a spongy shock absorber, sweeping nutrients into the cartilage. Joint cartilage has no blood supply thus all of its nourishment and lubrication comes from the fluid that ebbs and flows as pressure is applied and released to the joint. 2.) Without this fluid, cartilage would become malnourished, drier, thinner and more fragile. HOW CHONDROITIN SULPHATE WORKS: Chondroitin Sulphate is a long chain molecule with a negative charge attached to it. As these chains wrap around proteoglycans they repel each other and thus create spaces between each proteoglycan. These are what are known as matrixes within the cartilage and this is where the fluid flows. There may be as many as 10,000 of these chains on a single proteoglycan molecule—thus we have a super water retainer as these chains make sure all of the molecules are away from each other. Besides drawing in precious fluid, chondroitin protects cartilage, stops it from breaking down and inhibits certain “cartilage chewing” enzymes from interfering with the metabolism of other enzymes that will starve the cartilage of fluid. MSM (Methylsulfonylmethane): Promotes Healthy Inflammation Response MSM is a naturally occurring nutrient and sulfur compound. Sulfur is a component of bones, teeth and collagen (the protein in connective tissue) and also helps you maintain a healthy inflammatory response in joint tissue. The mineral sulfur is needed for the manufacture of many proteins, including those forming hair, muscles, and skin.   HYALURONIC ACID:   Hyaluronic Acid is plentiful in our bodies when we are born, but its levels gradually recede over time. Hyaluronic Acid occurs in the deeper layers of our skin known as the dermis and it appears to help keep the skin smooth because of its water retention qualities. Hyaluronic Acid also effectively helps repair skin wounds. Hyaluronic acid’s function is to cushion and lubricate. Hyaluronan occurs throughout the body in abundant amounts in many of the places people with hereditary connective tissue disorders have problems such as joints, heart valves and eyes. Hyaluronic acid abnormalities are a common thread in connective tissue disorders. Interestingly, they are also common biochemical anomalies in most of the individual features of connective tissue disorders such as mitral valve prolapse, TMJ, osteoarthritis and keratoconus.   BOSWELLIA EXTRACT:   Boswellia serrata (Sallai Guggal) is an ancient sap-producing tree that is grown throughout Western and Central China. When the tree trunk is tapped, a gummy oleoresin is exuded. A purified extract of this resin is used in modern herbal preparations.   The active compound in boswellia sap is boswellic acid, and it has been shown to have anti-inflammatory effects. The Boswellia from Puritan Pride is standardised to contain 65% of boswellic acids. Studies have shown that boswellic acids have an anti-inflammatory action—much like the conventional non-steroidal anti-inflammatory drugs (NSAIDs) used for inflammatory conditions. Boswellia inhibits pro-inflammatory mediators in the body, such as leukotrienes. As opposed to NSAIDs, long-term use of boswellia does not appear to cause irritation or ulceration of the stomach. Boswellic acid is thought to exert anti-inflammatory effects by preventing the breakdown of connective tissue, and by increasing the blood supply to joint tissues. In one study, boswellia performed better than prescription drugs at reducing the inflammation of osteo and rheumatory arthritis. It also sometimes performs better than aspirin, acetaminophen and other NSAIDS (non-steroidal anti-inflammatory aides) at reducing general arthritis pain.   VITAMIN D3:   Known as the sunshine vitamin, Vitamin D3 can be found in small amounts in a few foods, including fatty fish such as herring, mackerel, sardines and tuna. To make Vitamin D more available, it is added to dairy products, juices, and cereals.  But most Vitamin D (80% to 90% of what the body gets) is obtained through exposure to sunlight.     Vitamin D3 is also used for treating weak bones (osteoporosis), bone pain (osteomalacia), bone loss in people with a condition called hyperparathyroidism and an inherited disease (osteogenesis imperfecta) in which the bones are especially brittle and easily broken. It is also used for preventing falls and fractures in people at risk for osteoporosis, and preventing low calcium and bone loss (renal osteodystrophy) in people with kidney failure. How Long Should I Take Glucosamine/Chondroitin/MSM/Hyaluronic Acid/Boswellia Extract/Vitamin D3? Studies show that long-term usage of Glucosamine/Chondroitin/MSM/Hyaluronic Acid/Boswellia Extract/Vitamin D3 is most beneficial. Most patients see benefits within three to six months of regular usage.