Deus Ex‎:‎ Mankind Divided directly follows the aftermath of the Aug Incident‎,‎ a day when mechanically augmented citizens all over the world were stripped of control over their minds and bodies‎,‎ resulting in the deaths of millions of innocents‎.‎ The year is now 2029‎,‎ and the golden era of augmentations is over‎.‎

Mechanically augmented humans have been deemed outcasts and segregated from the rest of society‎.‎

Crime and acts of terror serve as a thin veil to cover up an overarching conspiracy aimed at controlling the future of mankind