Is adaptive randomization always better than traditional fixed‎-schedule randomization‎?‎ Which procedures should be used and under which circumstances‎?‎ What special considerations are required for adaptive randomized trials‎?‎ What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive randomization designs‎?‎ Modern Adaptive Randomized Clinical Trials‎:‎ Statistical and Practical Aspects answers these questions and more‎.‎ From novel designs to cutting‎-edge applications‎,‎ this book presents several new and key developments in adaptive randomization‎.‎ It also offers a fresh and critical look at a number of already‎-classical topics‎.‎Featuring contributions from statisticians‎,‎ clinical trialists‎,‎ and subject‎-matter experts in academia and the pharmaceutical industry‎,‎ the text‎:‎ * Clarifies the taxonomy of the concept of adaptive randomization * Discusses restricted‎,‎ covariate‎-adaptive‎,‎ response‎-adaptive‎,‎ and covariate‎-adjusted response‎-adaptive ‎(‎CARA‎)‎ randomization designs‎,‎ as well as randomized designs with treatment selection * Gives an exposition to many novel adaptive randomization techniques such as brick tunnel randomization‎,‎ targeted least absolute shrinkage and selection operator ‎(‎LASSO‎)‎‎-based CARA randomization‎,‎ multi‎-arm multi‎-stage ‎(‎MAMS‎)‎ designs‎,‎ to name a few * Addresses the issues of statistical inference following covariate‎-adaptive and response‎-adaptive randomization designs * Describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma * Explores some practical aspects of phase II dose‎-ranging studies and examines statistical monitoring and interim analysis issues in response‎-adaptive randomized clinical trials Modern Adaptive Randomized Clinical Trials‎:‎ Statistical and Practical Aspects covers a wide spectrum of topics related to adaptive randomization designs in contemporary clinical trials‎.‎The book provides a thorough exploration of the merits of adaptive randomization and aids in identifying when it is appropriate to apply such designs in practice‎.‎

• Author‎:‎ Oleksandr Sverdlov
• Publisher‎:‎ Chapman & Hall/CRC
• ISBN‎:‎ 9781482239881