This issue of the Medical Clinics of North America brings the practicing clinician up to date on the current challenges‎,‎ new concepts‎,‎ and management of hypertensive disease‎.‎ Topics covered include risks in hypertension‎;‎ new biological concepts of target organ involvement in hypertension‎;‎ hypertension and the metabolic syndrome‎;‎ aging versus hypertension‎;‎ hypertension‎,‎ systolic blood pressure‎,‎ and large arteries‎;‎ oxidative stress‎,‎ endothelial dysfunction‎,‎ and hypertension‎;‎ current thinking about hypertensive heart disease‎;‎ diastolic dysfunction as a link between hypertension and heart failure‎;‎ hypertension and cardiac failure in its various forms‎;‎ hypertension and atherogenesis‎;‎ the kidney‎,‎ hypertension‎,‎ and remaining challenges‎;‎ current thinking about renovascular hypertension‎;‎ obesity and hypertension‎;‎ and barriers to adherence in hypertension management‎.‎