Uses & Benefits of Black Nightshade Medicinal: The juice of black nightshade is sometimes used to treat fever and alleviate pain. Its fruit is used as a cosmetic; as rubbing its seeds on the cheeks helps remove freckles. Children extensively eat the mature fruit. It has been used for diabetes as well. In Northern India, the boiled extracts of its leaves and fruits are used to alleviate the discomfort caused by liver-related ailments, even in jaundice. The leaves of black nightshade plant strongly promote perspiration, when ingested in small amounts. They work to purge the bowels the next day. The juice of the herb or an ointment prepared from it is externally applied to cure certain skin problems and tumors. A decoction of the stalk, leaves, and roots of black nightshade is beneficial for wounds and cancerous