INDICATIONS AND USAGE:Minoxin (Minoxidil Topical Solution USP) is indicated for treatment of androgenetic alopecia, expressed in males as baldness of the vertex of the scalp and in females as diffuse hair loss or thinning of frontoparietal area. At least, 4 (four) months of twice daily application of Minoxin (Minoxidil Topical Solution USP) are generally required before evidence of hair growth can be expected.CONTRA-INDICATION:Minoxin (Minoxidil Topical Solution USP) is contra-indicated in those patients with a history of hypersensitivity to any component of the preparation.PRECAUTIONS AND WARNINGS:Although the following effects have not been associated with the topical use of Minoxidil solution there is some absorption (on average 1.4 %) from the scalp. The potential exists for systemic effects such as tachycardia, angina, oedema and potentiation of orthostatic hypotension produced by guanethidine. Patients should be observed periodically for any such systemic effects. In the event of systemic side-effect or severe dermatologic reaction discontinue administration of the drug.Minoxin (Minoxidil Topical Solution USP) will cause burning and irritation to the eye. In the event of accidental contact with sensitive surface (eye, abraded skin, mucous membranes), the area should be bathed with copious amounts of cool tap water. Minoxin (Minoxidil Topical Solution USP) should not be used in conjunction with other topical agents including corticosteroids, retinoids and petrolatum or agents that are known to enhance cutaneous drug absorption.USE DURING PREGNANCY AND LACTATION:Minoxin (Minoxidil Topical Solution USP) like other drugs should not be used by pregnant and nursing women.OVERDOSAGE AND ACCIDENTAL INGESTION:Accidental ingestion may produce systemic effects related to the vasodilatory action of Minoxidil. Signs and symptoms of drug overdosage would most likely be cardiovascular effects associated with fluid retention, lowered blood pressure and tachycardia. Fluid retention can be managed with appropriate diuretic therapy. Tachycardia can be controlled by administration of a beta adrenergic blocking agent.Hypotension should be treated by intravenous administration of normal saline. Sympathomimetic drugs, such as norepinephrine and epinephrine should be avoided because of their excessive cardiac stimulating activity.DOSAGE AND ADMINISTRATION:For external use only. Use Minoxin only as directed. Do not apply to any other area of the body. A total dose of 1 ml Minoxin should be applied twice daily on the scalp, beginning at the center of the affected area. This dose should be used regardless of the size of the affected area. Six pumps of the applicator release approx. 1 ml of Minoxin. The total daily dose should not exceed 2 ml. To avoid any systemic absorption, wash hands thoroughly after applying Minoxin. Apply Minoxin when the hair and scalp are thoroughly dried. Don’t use a hairdryer to speed the drying of Minoxin solution because blowing air on the scalp may decrease the effectiveness of Minoxin.