SUPERFLEX-3 Cream Joint Care Formula contains key ingredients which have been proven through recent clinical studies to provide relief from the pain of many arthritic conditions and in particular osteoarthritis. This deep penetrating formula provides prolonged release action of MSM, Glucosamine and Chondroitin through a transdermal delivery system.

SUPERFLEX-3 Cream Joint Care Formula​ is designed to:  • Help support muscles, cartilage, tendons, and joints • Help support healthy levels of collagen and keratin • Support for skin softening and firming • Help to temporarily reduce joint pain and inflammation SUPERFLEX-3 Cream Joint Care Formula provides quick topical relief to inflamed joints and sore muscles caused by overwork, daily activity, or arthritis. SUPERFLEX-3 Cream Joint Care Formula works with the body's natural hormones to provide quick, safe, pain relief. Used regularly, it can act as a preventive measure. What are the main ingredients in SUPERFLEX-3 Cream Joint Care Formula?  One of the most important ingredients in SUPERFLEX-3 Cream Joint Care Formula is MSM or Methylsulfonylmethane. SUPERFLEX-3 Cream Joint Care Formula is made with OptiMSM®. OptiMSM® is manufactured in a GMP-FDA approved facility and is the only MSM supported by double blind clinical research. OptiMSM® is held to the highest quality standards, tested by independent laboratories to guarantee the absence of harmful metal and biological contaminants, and is always guaranteed 99.9% pure methylsulfonylmethane. OptiMSM® is the world’s purest methylsulfonylmethane (MSM). Every batch of OptiMSM® is distilled for purity and undergoes the most rigorous analytical testing available, guaranteeing unsurpassed quality. MSM is an organic sulfur-containing nutrient that supports healthy active lifestyles by providing nutritionally essential sulfur and methyl groups. OptiMSM® works by inhibiting the pain impulses along nerve fibers, lessening of inflammation, increasing of blood supply, reducing muscle spasms, and softening of scar tissue. Some key points about MSM:  • Acts as an analgesic (Relieves pain) • Anti-inflammatory (Reduces inflammation) • May slow down the degeneration of cartilage • Passes through cellular membranes of the body, including the skin • Potential for rendering cell membranes more permeable (may increase the effectiveness of the body's own natural painkillers) • Dilates blood vessels (vasodilation) and increases blood flow • Cholinesterase inhibitor (Cholinesterase blocks nerve impulses,  preventing the brain and body from working properly) • Reduces muscle spasm; topically, the effects are localized; internally the effect is generalized among the muscle groups • Alters cross-linking process in collagen, reducing scar tissue • Synergizes with Glucosamine Sulfate Other key ingredients in SUPERFLEX-3 Cream Joint Care Formula​: The other two main ingredients in SUPERFLEX-3 Cream Joint Care Formula are Glucosamine and Chondroitin.  Glucosamine:  Healthy cartilage needs three things: water for lubrication and nourishment, proteoglycans to attract and hold the water, and collagen to keep the proteoglycans in place. Proteoglycans are like a rope that threads itself through the collage and are essential as they hold many times their own weight of water, which both lubricates and nourishes the collagen. If the cartilage is damaged the thread of rope becomes weak and ‘leaks’ out and thus the collagen loses its nourishment as the proteoglycans lose their grip and float away. Thus the cartilage cannot withstand shocks, cracks and may wear out completely. Glucosamine is a major building block of the water – loving proteoglycans. Besides being a building block for the synthesis of proteoglycans, its mere presence acts as a stimulus to the cells that produce proteoglycans – in fact glucosamine is a key factor in determining how many proteoglycans are produced by the cells. Glucosamine has been shown to speed up production of both proteoglycans and collagen and it normalises cartilage metabolism which helps keep cartilage from breaking down. Thus because of the affect of glucosamine on cartilage metabolism it can in fact help the body to repair damaged or eroded cartilage. In other words, glucosamine strengthens your body’s natural repair mechanisms. Besides stimulating cartilage production, glucosamine also reduces joint pain and inflammation. Where glucosamine helps form the proteoglycans that sit within the space in the cartilage, chondroitin sulphate acts like ‘liquid magnets’. Chondroitin is a long chain of repeating nigans that attracts fluid into the proteoglycan molecules.  This is important for two reasons: The fluid acts as a spongy shock absorber. The fluid sweeps the nutrients into the cartilage. Joint cartilage has no blood supply thus all of its nourishment and lubrication comes from the fluid that ebbs and flows as pressure is applied and released to the joint. Without this fluid, cartilage would become malnourished, drier, thinner and more fragile. Chondroitin:  Chondroitin Sulphate is a long chain molecule with a negative charge attached to it. As these chains wrap around proteoglycans they repel each other and thus create spaces between each proteoglycan. These are what are known as matrixes within the cartilage and this is where the fluid flows. There may be as many as 10,000 of these chains on a single proteoglycan molecule – thus we have a super water retainer as these chains make sure all these molecules are away from each other and cannot clump together. Besides drawing in precious fluid, chondroitin: Protects cartilage and stops it from breaking down and inhibits certain ‘cartilage chewing’ enzymes interferes with the metabolism of other enzymes that will starve the cartilage of fluid stimulates production of proteoglycans, glucosamine and collagen. Clinical research:  Results of a recent clinical study published in the Journal of Rheumatology show long term benefits of topical application of a preparation containing glucosamine and chondroitin sulfate. The research shows continuous reduction of pain resulting from osteoarthritis of the knee, with clinically significant results within four weeks. According to the study’s principal investigator, the information also suggests that topical application of these agents is an effective route of administration. Nearly all of the patients using the cream obtained immediate pain relief. Additionally, the results showed there was a greater mean sustained reduction in pain at both four weeks and eight weeks for the experiment group compared to the placebo group. A majority of the cream users experienced gradually and continually improving pain relief over the eight weeks. A surprising result was that with continued use, one-third of the experiment group had their chronic osteoarthritis pain completely or nearly completely eliminated within eight weeks or less. According to Marc Cohen, MD, PhD, Department of Complementary Medicine, Faculty of Life Sciences, RMIT University, and principal investigator of this study, "The observed gradual and continual improvement in pain scores is likely to be due to the glucosamine and chondroitin content and this is consistent with previous studies." (J Rheumatol 2003;30:523-8)