* Indications:
Bronchial asthma. Chronic bronchitis, emphysema and other lung diseases, where bronchospasm
is a complicating factor.
* Dosage and method of administration:
- Bambec should be used as maintenance therapy in asthma and other pulmonary diseases where
bronchospasm is a complicating factor.
- Bambec is dosed once daily, preferably shortly before bed-time The dose should be individual.
# Adults: The recommended initial dose is 10 mg. The dose may be increased to 20 mg after 1-2 weeks,
depending on the clinical effect. In patients who previously have tolerated oral beta2-agonists well,
the recommended initial dose is 20 mg.
# In patients with an impaired renal function (GFR 5 mg, which may be increased to 10 mg after 1-2 weeks, depending on the clinical effect.
# Elderly: Dosage as for adults.
# Children 2-5 years: The recommended normal dose is 10mg and, because of differences in
kinetics, 5 mg # Children 6-12 years: The recommended initial dose is 10 mg. The dose may be increased to
20 mg after 1-2 weeks, depending on the clinical effect.
Because of differences in kinetics, doses above 10 mg are not recommended in Oriental children.
* Special warnings and Precautions for use:
- As terbutaline is excreted mainly via the kidneys, the dose of Bambec should be halved in
patients with an impaired renal function (GFR - In patients with liver cirrhosis, and probably in patients with other causes of severly impaired
liver function, the daily dose must be individualized, taking into account the possibility that
the individual patient could have an impaired ability to metabolize bambuterol to terbutaline.
Therefore, from a practical point of view, the direct use of the active metabolite, terbutaline
(Bricanyl), is preferable in these patients.
- As for beta2-agonists, caution should be observed in patients with thyrotoxicosis and in
patients with severe cardiovascular disorder, such as ischemic heart disease, tachyarrhythmias
or severe heart failure.
- Due to the hyperglycemic effects of beta2-agonists, additional blood glucose controls are
recommended initially in diabetic patients.
- Potentially serious hypokalemia may result from beta2-agonist therapy. Particular caution is
recommended in acute severe asthma as the associated risk may be augmented by hypoxia.
The hypokalemic effect may be potentiated by concomitant treatments. It is recommended that
serum potassium levels are monitored in such situations.
* The tablet can be divided by putting it on a flat surface and pressing it gently.
* Do not store above 30 degrees C.
* AstraZeneca AB - Sweden. Imported by: Healthy family.