For over half a century‎,‎ this book has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists‎.‎ Fully updated for the Twelfth Edition‎,‎ coverage begins with the fundamental principles of chemistry‎,‎ biochemistry‎,‎ and biology that underlie the discipline of medicinal chemistry‎.‎ These principles are then applied to understanding the properties‎,‎ mode of action‎,‎ therapeutic applications‎,‎ and limitations of various pharmaceutical agents‎.‎ The subject matter is organized by pharmaceutical and therapeutic classes‎,‎ providing a bridge between the basic sciences and clinical practice‎.‎ The text contains many tables for quick reference to names‎,‎ formulations‎,‎ dosages‎,‎ and applications‎.‎ This edition includes chapter review questions‎.‎ A companion website provides answers to the review questions for students and an image bank for faculty‎.‎