While patients with metastatic renal cell carcinoma ‎(‎mRCC‎)‎ are now living longer with improved quality of life‎,‎ the success of novel therapies for mRCC has created challenges for practicing oncologists‎.‎ Many patients who initially respond to targeted therapies ultimately develop progressive disease due to acquired resistance to these agents‎.‎ Additionally‎,‎ some patients do not respond at all to any of the currently approved targeted agents‎,‎ underscoring the need for continued and concerted efforts to identify other relevant targets and pursue alternative therapeutic strategies‎.‎ Part of the Oxford American Oncology Library‎,‎ Renal Cell Carcinoma is a concise handbook that addresses the complex management of patients with mRCC‎.‎ The book begins with a review of the epidemiology‎,‎ pathology‎,‎ and biology of renal cell carcinoma followed by chapters on specific targeted therapies and managing complications‎.‎ The final chapters discuss supportive and integrative care and emerging therapies‎.‎