* Indications: & & Marpalene Cream is indicated for the topical treatment of acne vulgaris. * Dosage and administration: & & Marpalene Cream should be applied to the affected areas of the skin, once daily at night time. & & A thin film of the cream should be applied to the skin areas where acne lesions appear, using & & enough to cover the entire affected areas lightly. A mild transitory sensation of warmth or slightly & & stinging may occur shortly after the application of Marpalene Cream. * Contraindications: & & Marpalene Cream should not be administered to individuals who are hypersensitive to adapalene & & or any of the components in the cream vehicle. * Pregnancy and lactation: & & – Marpalene Cream should be used during pregnancy only if the potential benefit justifies the potential & & risk to the fetus. & & – Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs & & are excreted in human milk, caution should be exercised when Marpalene Cream is administered & & to a nursing woman. * Warnings and precautions: & & – Certain cutaneous signs and symptoms of treatment such as erythema, dryness, scaling, burning, or & & pruritus may be experienced with use of Marpalene Cream. These are most likely to occur during the & & first two to four weeks of treatment, mostly mild to moderate in intensity, and usually lessen with & & continued use of the medication. Depending upon the severity of these side effects, patients should & & be instructed to reduce the frequency of application or discontinue use. & & – If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be & & discontinued. & & – Exposure to sunlight, including sunlamps, should be minimized during use of adapalene. Patients who & & normally experience high levels of sun exposure, and those with inherent sensitivity to sun, should be & & warned to exercise caution. Use of sunscreen products and protective clothing over treated areas is & & recommended when exposure cannot be avoided. & & – Whether extremes, such as wind or cold, also may be irritating to patients under treatment with adapalene. & & – Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. & & – The product should not be applied to cuts, abrasions, eczematous or sunburned skin. & & – As with other retinoids, use of “waxing” as a depilatory method should be avoided on skin treated with & & adapalene. * For external use only. Store at temperature not exceeding 30 degrees C. * Manufactured by: Marcyrl Pharmaceutical Industries – Egypt.