Janeway‎'‎s Immunobiology is a textbook that introduces the immune system in all its aspects to undergraduates‎,‎ and also provides a treatment of the subject that is comprehensive enough to be useful to graduate students interested in research‎,‎ and to medical students focused on clinical applications‎.‎ The Eighth Edition has been thoroughly revised and updated and is available in both print and e‎-book formats‎.‎ Janeway‎'‎s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization‎,‎ uniform art program‎,‎ and scientific accuracy‎.‎ It presents a consistent point of view throughout‎-that of the host‎'‎s interaction with an environment containing many species of potentially harmful microorganisms‎.‎ The full‎-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text‎.‎ The 16 chapters in this readable‎,‎ accessible textbook are organized and presented in such a way as to help deliver a complete one‎-semester immunology course‎,‎ beginning with innate immunity‎,‎ then moving to adaptive immunity‎,‎ and ending with applied clinical immunology‎.‎ Discussion questions are provided at the end of Chapters 2 to 16‎.‎ These questions can be used for review‎,‎ or as the basis for discussion in class or in informal study groups‎.‎ Summaries conclude each section and each chapter‎.‎ As in previous editions‎,‎ a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology‎,‎ Sixth Edition by Geha and Notarangelo‎.‎ New in the Eighth Edition *Innate immunity has been updated and expanded and is now presented in two separate chapters ‎(‎Chapters 2 and 3‎)‎‎,‎ as well as being further emphasized in the rest of the textbook‎.‎ Chapter 2 covers antimicrobial peptides and the complement system‎,‎ and Chapter 3 deals with cellular innate receptors and cell‎-mediated innate immunity ‎(‎e‎.‎g‎.‎ TLRs‎,‎ phagocytosis‎,‎ NK cells‎,‎ interferon production‎,‎ innate‎-like lymphocytes‎)‎‎.‎ * The section on complement has been reworked and reconceived‎-explaining the lectin pathway first‎-making it easier to teach by placing it into the context of innate recognition‎.‎ *Evolution is now incorporated throughout the text‎,‎ helping students see similar strategies used by different organisms‎.‎ * The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology‎,‎ focusing on improved illustration of antigen recognition signaling and lymphocyte activation‎.‎ Signaling through other receptors is dealt with wherever appropriate throughout the book‎.‎ * Updated chapter on B‎-cell immune responses ‎(‎Chapter 10‎)‎‎,‎ especially on trafficking of B cells in peripheral lymphoid organs ‎(‎e‎.‎g‎.‎ lymph nodes‎)‎ and the locations at which they encounter antigen‎.‎ * Coverage of mucosal immunity ‎(‎Chapter 12‎)‎ has been brought up to date‎,‎ including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria‎.‎ * Chapter 13‎,‎ Failures of Host Defense Mechanisms‎,‎ has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways‎.‎ * Chapter 16‎,‎ Manipulation of the Immune Response‎,‎ has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines‎.‎ *Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text‎.‎ * The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways‎.‎ * New references have been added throughout the text‎.‎