Despite recent advances‎,‎ therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas‎,‎ because of the presence of the blood‎-brain barrier‎.‎ Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment‎.‎ Their nanometric size‎,‎ electrostatic charge‎,‎ and lipophilic characteristics allow them to penetrate into the brain tissue freely‎.‎ Promising in‎-vitro results have been reported‎,‎ but remain to be validated in humans‎.‎ This title focuses on the blood‎-brain barrier pathophysiology in brain tumors‎,‎ and the possibilities of overcoming this with nanoparticle‎-based systems‎.‎ Relevant patents of nanoparticles used as drug delivery carriers are also reported‎,‎ as well as future scenarios in nanoparticles and stem cells‎.‎