Nike Downshifter 10. Women's Running Shoe. 2-TONE SHIFT. The Nike Downshifter 10 features a lightweight mesh upper that provides breathable comfort. Closed mesh on the heel and midfoot gives structured support for sprints. The sole features flex grooves that bend with you while full-length foam softly cushions every step. Closed mesh through the midfoot and heel provides structured support. Mesh upper gives breathable comfort. Soft, smooth midsole cushions your stride.